The Effect of Topical Phenytoin Application on Traumatic Tympanic Membrane Perforation

Kuran G., Ide T., Ceylan B. T., Sirin Y. S., Yilmazer D., Vuralkan E.

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, cilt.9, sa.3, ss.343-348, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 3
  • Basım Tarihi: 2013
  • Dergi Adı: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.343-348
  • Gazi Üniversitesi Adresli: Hayır

Özet

Objective: To determine the effect of topical phenytoin on healing of tympanic membrane in rabbits. Materials and Methods: Under otomicroscopy, a 4 mm perforation was created in the posterosuperior quadrants in both ears of eighteen healthy adult New Zealand white rabbits. Daily applications of topical phenytoin solution ( 0.5ml) to the right and isotonic saline ( 0.5 ml) to the left ear were continued until sacrification of the animal. Six rabbits were randomly sacrificed on day 3, then 6 more were sacrificed on days 7 and 14 respectively in order to examine the vascularization, inflammation and fibroblastic reaction process in different stage. Results: There was no significant difference between the phenytoin group and control group in terms of inflammation, neovascularization and fibroblastic reaction. Conclusion: Topical phenytoin application to an acute traumatic tympanic membrane perforation does not have a significant effect in this study.