Akademik Veri Yönetim Sistemi
3rd International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2020), Ankara, Türkiye, 19 - 20 Mart 2020, ss.34-39
Autism
spectrum disorder is defined as a set of neurodevelopmental disorder,
characterized by repetitive behaviors, restricted interests, social deficits
and communication difficulties.
Although
the number of cases of ASD diagnosed over the last four decades has increased
significantly, there is still considerable debate about the underlying
pathophysiology of ASD. It is now seen that it affects 1.5% of the world's
population and disproportionately affects men.
The
aim of this retrospective study was to evaluate the hematology blood parameters
of children with autism.
The
study included 30 children with autism aged between 10 and 18 years and 30
healthy children as a control group. The autism group was selected from the
children with autism diagnosis in the Department of Pediatric Neurology at Gazi
University Faculty of Medicine between 2018-2019 and the control group was
selected from the Children's Health Unit. For the study, the ethics committee
permission was obtained from the meeting on 28.05.2018 (decision number: 430)
from Gazi University Clinical Research Ethics Committee. In two groups, routine
hematology parameters were evaluated retrospectively.
According
to our study; mean erythrocyte volume (MCV), neutrophil count, neutrophil
percentage, lymphocyte percentage, are significantly different between autism
and control group (p<0,05).
The
high neutrophil lymphocyte ratio supports the hypothesis that there is a role
of neuroinflammation in the etiology of autism. The view that elevated levels
of neutrophil lymphocytes may be a guide in screening and early intervention in
autism may be the subject of new research.