Akademik Veri Yönetim Sistemi
Plastic and Reconstructive Surgery, 2025 (SCI-Expanded)
Background: Capsular contracture is a common complication in breast implant surgery, with subclinical bacterial inflammation being a significant factor. Traditional methods to prevent capsular contracture include antibiotic irrigation and systemic antibiotics. However, the rise of antibiotic-resistant bacteria has driven the need for alternative treatments. Bacteriophages, capable of lysing bacteria and preventing biofilm formation, are emerging as a potential alternative. This study aims to compare the efficacy of local bacteriophage therapy and local antibiotic treatment in preventing biofilm formation on breast implants. Material and Methods: Fifty-four Wistar Albino rats were divided into three groups: control, antibiotic, and bacteriophage, each with three subgroups for different time points (6 hours, 24 hours, and 30 days). Three types of implant surfaces (smooth, textured, and polyurethane) were incubated with a biofilm-producing strain of Staphylococcus epidermidis before implantation. The implant surfaces in the experimental groups were treated with either antibiotic or bacteriophage solutions before implantation. Samples were collected at 6 hours, 24 hours, and 30 days post-implantation for colony counting and mRNA analysis of the sesI gene. Results: Both bacteriophage and antibiotic treatments significantly reduced colony counts, and mRNA expression compared to the control group at all time points (p<0.05). No significant difference was found between the antibiotic and bacteriophage groups. Textured and polyurethane implants showed lower bacterial loads in the experimental groups compared to smooth implants. Conclusion: This study highlights bacteriophages as a promising alternative to antibiotics for preventing biofilm formation on breast implants, representing a pioneering effort in demonstrating their potential.