Oxidative stress-induced apoptotic changes after acute exposure to antifouling agent zinc pyrithione (ZnPT) in Mytilus galloprovincialis Lamark (Mediterranean mussels) tissues

Katalay S., Guner A., DAĞDEVİREN M., Yigitturk G., YAVAŞOĞLU A., GÜNAL A. Ç., ...Daha Fazla

CHEMISTRY AND ECOLOGY, cilt.38, sa.4, ss.356-373, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/02757540.2022.2047951
  • Dergi Adı: CHEMISTRY AND ECOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Agricultural & Environmental Science Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Environment Index, Food Science & Technology Abstracts, Geobase, Pollution Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.356-373
  • Anahtar Kelimeler: Mussel, zinc pyrithione, apoptosis, histology, biochemical effects, micronuclei, HISTOLOGICAL-CHANGES, DIGESTIVE GLAND, ACUTE TOXICITY, COPPER, GILLS, GLUTATHIONE, BIOMARKER, HEPATOPANCREAS, EMBRYOTOXICITY, ACCUMULATION
  • Gazi Üniversitesi Adresli: Evet

Özet

Zinc pyrithione (ZnPT) is one of the components used in antifouling paints and can be an alternative to classical toxic chemicals such as organotin. However, there is still remarkable concern about the environmental safeness of ZnPT due to rapid transchelation and degradation into several metabolites that have their own toxicity. The effect after acute exposure of ZnPT is investigated on Mediterranean mussels exposed to 20 and 40 mu g/L concentrations for 48 and 96 h and antioxidant responses [superoxide dismutase (SOD), and reduced glutathione (GSH)], genotoxicity [micronuclei (MN) frequency], apoptotic and histological changes were determined. Severe histological changes in hepatopancreas and gill tissues of mussels were observed in ZnPT exposed groups due to dose-dependent increase. ZnPT also caused a dose-dependent increase of TUNEL-positive cell count in the mussel tissues, especially in the hepatopancreas. Increasing in SOD activities and decreasing in GSH levels in both ZnPT concentrations compared to the control were observed. MN and binuclei numbers in all exposure groups were significantly increased. The results of the present study demonstrate that acute exposure to ZnPT could cause an adverse effect on mussel tissues at especially higher concentrations.