Metoclopramide inhibits trigeminovascular activation: evidence for effective acute attack treatment in migraine

Doganay Aydin H., VURALLI D., AKÇALI D. T., Bolay H. B.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.1, pp.343-347, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.3906/sag-1601-195
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.343-347
  • Keywords: Metoclopramide, trigeminal nucleus caudalis, D-2 receptors, raclopride, trigeminovascular system, migraine, rat, DOPAMINE, METAANALYSIS, PREVENTION, MODEL
  • Gazi University Affiliated: Yes

Abstract

Background/aim: Metoclopramide is an effective and commonly used medication in acute migraine treatment but an experimental evidence base is lacking. We aimed to investigate the antimigraine effect of metoclopramide in a migraine model and whether the analgesic effect of metoclopramide was likely to be D-2 receptor-mediated.