Metoclopramide inhibits trigeminovascular activation: evidence for effective acute attack treatment in migraine

Doganay Aydin H., VURALLI D., AKÇALI D. T., Bolay H. B.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.47, sa.1, ss.343-347, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3906/sag-1601-195
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.343-347
  • Anahtar Kelimeler: Metoclopramide, trigeminal nucleus caudalis, D-2 receptors, raclopride, trigeminovascular system, migraine, rat, DOPAMINE, METAANALYSIS, PREVENTION, MODEL
  • Gazi Üniversitesi Adresli: Evet

Özet

Background/aim: Metoclopramide is an effective and commonly used medication in acute migraine treatment but an experimental evidence base is lacking. We aimed to investigate the antimigraine effect of metoclopramide in a migraine model and whether the analgesic effect of metoclopramide was likely to be D-2 receptor-mediated.