Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontiti and coronary artery disease

Tueter, GÜLAY; Kurtis, MAZLUM; SERDAR, Muhittin; Aykan, Tuba; Okyay, Kaan; Yuecel, AYŞEGÜL; Toyman, Utku; Pinar, Selin; Cemri, Mustafa; Cengel, ATİYE; Walker, Stephen; Golub, Lorne

doi:10.1111/j.1600-051x.2007.01104.x

Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontiti and coronary artery disease

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Tueter G., Kurtis B., SERDAR M. A., Aykan T., Okyay K., Yuecel A., ...More

JOURNAL OF CLINICAL PERIODONTOLOGY, vol.34, no.8, pp.673-681, 2007 (SCI-Expanded)

Publication Type: Article / Article
Volume: 34 Issue: 8
Publication Date: 2007
Doi Number: 10.1111/j.1600-051x.2007.01104.x
Journal Name: JOURNAL OF CLINICAL PERIODONTOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.673-681
Keywords: adjunctive treatment, cardiovascular disease, C-reactive protein, gingival crevicular fluid/analysis, host modulation therapy, matrix metalloproteinases, periodontitis/therapy, plasma lipids, subantimicrobial dose doxycycline, C-REACTIVE PROTEIN, GINGIVAL CREVICULAR FLUID, MATRIX-METALLOPROTEINASE INHIBITOR, MYOCARDIAL-INFARCTION, INFLAMMATORY MARKERS, COLLAGENASE ACTIVITY, TREPONEMA-DENTICOLA, ADULT PERIODONTITIS, RISK, INFECTIONS
Gazi University Affiliated: Yes

Abstract

Objectives: This study evaluated the effects of scaling and root planing (SRP) +/- sub-antimicrobial dose doxycycline (SDD) on gingival crevicular fluid (GCF) levels of matrix metalloproteinase (NIMP) -1, -8, -13 and on serum levels of high-sensitivity C-reactive protein (HsCRP) and lipid fractions in patients with both chronic periodontitis (CP) and coronary artery disease (CAD).