Alzheimer's Disease and Protein Kinases

ENGİN A. B., ENGİN A.

PROTEIN KINASE-MEDIATED DECISIONS BETWEEN LIFE AND DEATH, cilt.1275, ss.285-321, 2021 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1275
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/978-3-030-49844-3_11
  • Dergi Adı: PROTEIN KINASE-MEDIATED DECISIONS BETWEEN LIFE AND DEATH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.285-321
  • Anahtar Kelimeler: Alzheimer's disease (AD), N-methyl-D-aspartate receptor (NMDAR), Amyloid precursor protein (APP), Amyloid beta (Abeta), Tau, Abeta-derived diffusible ligand (ADDL), Ephrin B receptor, Cytosolic p21-activated kinase (PAK), Neurofibrillary tangle (NFT), Type 3 diabetes, AMYLOID PRECURSOR PROTEIN, BRAIN INSULIN-RESISTANCE, INFLAMMATORY MICROGLIAL ACTIVATION, EXTRASYNAPTIC NMDA RECEPTORS, TRANS-GOLGI NETWORK, A-BETA, OXIDATIVE STRESS, MOUSE MODEL, TAU-PROTEIN, NEUROTROPHIC FACTOR
  • Gazi Üniversitesi Adresli: Evet

Özet

Alzheimer's disease (AD) is the most common neurodegenerative disorder and accounts for more than 60-80% of all cases of dementia. Loss of pyramidal neurons, extracellular amyloid beta (Abeta) accumulated senile plaques, and neurofibrillary tangles that contain hyperphosphorylated tau constitute the main pathological alterations in AD.