Effectiveness of scaling and root planing versus modified Widman flap on nitric oxide synthase and arginase activity in patients with chronic periodontitis


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Gullu C., Ozmeric N. , Tokman B. , Elgun S., Balos M.

JOURNAL OF PERIODONTAL RESEARCH, vol.40, no.2, pp.168-175, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1600-0765.2005.00784.x
  • Title of Journal : JOURNAL OF PERIODONTAL RESEARCH
  • Page Numbers: pp.168-175
  • Keywords: arginase, nitric oxide synthase, periodontal treatment, periodontitis, HUMAN GINGIVAL FIBROBLASTS, EXPRESSION, TISSUE, INFLAMMATION, CYTOKINES, DISEASE, SALIVA, ADULT

Abstract

Background: Nitric oxide (NO) is synthesized from the conversion Of L-arginine to L-citrulline by NO synthase (NOS). Arginase, which is an arginine-depleting enzyme, can compete with NOS for the common substrate L-arginine and thus inhibit NO production.