The Effects of Memantine after Propofol Anaesthesia to Recovery on Cognitive Functions and Pain in Streptozotocin Induced Diabetic Rats

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Cicek E., KURTİPEK Ö., ARSLAN M., ÜNAL Y.

GAZI MEDICAL JOURNAL, vol.31, no.3, pp.339-344, 2020 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.12996/gmj.2020.83
  • Journal Name: GAZI MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier
  • Page Numbers: pp.339-344
  • Gazi University Affiliated: Yes

Abstract

Objective: The aim of this study is to research the neurocognitive, neuroprotective and analgesic effects of the memantine in diabetic rats after anaesthesia. Postoperative cognitive dysfunction is a frequent complication after anaesthesia. Although the reason of this hasn't been explained completely, there are numerous risk factors such as the increase of cognitive dysfunction during postoperative period. Being in older age, coexisting diseases, etc. are among these risk factors. Propofol, one of the anaesthetic agents, is an agent causing the postoperative cognitive dysfunction.Memantine has beneficial effects on memory deficits and learning process. Additionally, it is an agent which also has neuroprotective effects, and is used for the treatment of chronic pain syndromes. In this study, we aim to determine its effects on recovery, cognitive functions and pain of memantine after propofol anaesthesia.