Effects of stobadine and vitamin E in diabetes-induced retinal abnormalities: involvement of oxidative stress.


Yulek F., Or M., Ozogul C., Isik A. C. , Ari N., Stefek M., ...More

Archives of medical research, vol.38, no.5, pp.503-11, 2007 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 5
  • Publication Date: 2007
  • Doi Number: 10.1016/j.arcmed.2007.02.006
  • Title of Journal : Archives of medical research
  • Page Numbers: pp.503-11
  • Keywords: diabetic rat, stobadine, vitamin E, lipid peroxidation, VEGF, aldose reductase, retina, ENDOTHELIAL GROWTH-FACTOR, ALDOSE REDUCTASE INHIBITOR, IN-VIVO TREATMENT, PYRIDOINDOLE STOBADINE, ADVANCED GLYCATION, LIPID-PEROXIDATION, INDUCED ACTIVATION, FACTOR EXPRESSION, RATS, RETINOPATHY

Abstract

Background. Because hyperglycemia-induced oxidative stress may be a cause of retinopathy, this study examined the hypothesis that administration of exogenous antioxidants, stobadine (ST) and vitamin E (vitE), can restore retinal abnormalities in experimental diabetes.