Effects of stobadine and vitamin E in diabetes-induced retinal abnormalities: involvement of oxidative stress.

Yulek F., Or M., Ozogul C., Isik A. C., Ari N., Stefek M., ...Daha Fazla

Archives of medical research, cilt.38, sa.5, ss.503-11, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 5
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.arcmed.2007.02.006
  • Dergi Adı: Archives of medical research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.503-11
  • Anahtar Kelimeler: diabetic rat, stobadine, vitamin E, lipid peroxidation, VEGF, aldose reductase, retina, ENDOTHELIAL GROWTH-FACTOR, ALDOSE REDUCTASE INHIBITOR, IN-VIVO TREATMENT, PYRIDOINDOLE STOBADINE, ADVANCED GLYCATION, LIPID-PEROXIDATION, INDUCED ACTIVATION, FACTOR EXPRESSION, RATS, RETINOPATHY
  • Gazi Üniversitesi Adresli: Evet

Özet

Background. Because hyperglycemia-induced oxidative stress may be a cause of retinopathy, this study examined the hypothesis that administration of exogenous antioxidants, stobadine (ST) and vitamin E (vitE), can restore retinal abnormalities in experimental diabetes.