Akademik Veri Yönetim Sistemi
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, cilt.13, sa.11, ss.1237-1240, 2022 (ESCI)
Aim: As a mucolytic agent, Erdosteine has two sulfhydryl groups. These groups function as free radical scavengers, which has protective effects against ischemia- reperfusion (IR) injury. In this study, we aimed to observe the effects of erdosteine on skeletal muscle tissue in a rat lower extremity IR injury model. Material and Methods: A total of 18 Wistar albino rats were separated into 3 groups (n: 6); Control group (C), IR group (IR) and IR group with erdosteine (IR-E). Erdosteine administered intraperitoneally (150 mg.kg-1). Rat tissues were taken for histopathological and immunohistochemical evaluations after 2 hours of ischemia and 2 hours of reperfusion period. Results: Blood flow measurements were significantly higher in the IR-E group than in the IR group. In the IR group, endothelial caspase 3 and 8 enzyme expression was significantly higher than C and IR-E groups. Muscle caspase 3 enzyme expression was higher in the IR group than C and IR-E groups. IR and IR-E groups showed increased inflammation, vascular congestion and myositis injury levels than the C group. Also, inflammation, vascular congestion and myositis injury showed a significant decrease in the IR-E group than IR group. Discussion: As a result, erdosteine has a protective effect against skeletal tissue damage resulting from IR injury in rats. The results show the possibility of clinical administration of erdosteine for I/R injury of skeletal muscle tissue.