Effects of recurrent sevoflurane anesthesia on cognitive functions with streptozotocin induced Alzheimer disease


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Erkent F. D., Isik B., Kucuk A., Ozturk L., Neselioglu S., Dogan H. T., ...Daha Fazla

Bratislava Medical Journal, cilt.120, sa.12, ss.887-893, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 120 Sayı: 12
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4149/bll_2019_149
  • Dergi Adı: Bratislava Medical Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.887-893
  • Anahtar Kelimeler: Alzheimer, sevoflurane, Radial Arm Maze Test, rat, GFAP, Caspase-3, DYNAMIC THIOL/DISULPHIDE HOMEOSTASIS, DYSFUNCTION, MEMORY, SURGERY, PHOSPHORYLATION, OLIGOMERIZATION, ISOFLURANE, APOPTOSIS, EXPOSURE, PLASMA
  • Gazi Üniversitesi Adresli: Evet

Özet

© 2019 Comenius University.OBJECTIVE: We aimed to investigate the effects of recurrent sevoflurane anesthesia on cognitive functions in Alzheimer Disease. MATERIALS AND METHODS: Rats were divided into 4 groups as followed: control (Group C), sevoflurane (Group S), Alzheimer's (Group A) and Alzheimer's + sevoflurane (Group AS)]. Cognitive functions were evaluated with Radial Arm Maze Test (RAMT). Alzheimer model was created by administering 3 mg/kg (10 μl) STZ. Sevoflurane was administered to S and AS groups. Serum samples and hippocampus tissues were analyzed. RESULTS: In RAM test, the entry-exit data were significantly decreased in A and AS groups. After the 2nd and 3rd administration of anesthesia, the numbers were significantly decreased in Group S. Glial-fibrillaryacidic protein levels were significantly higher in AS compared to the C and S groups. The brain tissue caspase 3 activity was less than 1% in all rats in the Group C, 3 % in 2 rats and 1 % in 1 rat in the Group AS. In A and AS group, serum catalase, myeloperoxidase and ferroxidase activities were found to be higher than in the other groups and myeloperoxidase activity was higher in the AS than in the A Group. Serum native thiol, total thiol and disulfi de levels were found to be significantly different in the A and AS groups. CONCLUSION: Sevoflurane anesthesia negatively affected the cognitive functions (Tab. 5, Fig. 10, Ref. 51). Text in PDF www.elis.sk.