The Relationship of Severity of Autism with Gastrointestinal Symptoms and Serum Zonulin Levels in Autistic Children

Karagozlu S., DALGIÇ B., İŞERİ E.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, cilt.52, sa.2, ss.623-629, 2022 (SSCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s10803-021-04966-1
  • Dergi Adı: JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • Derginin Tarandığı İndeksler: Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ASSIA, PASCAL, BIOSIS, Child Development & Adolescent Studies, CINAHL, EBSCO Education Source, Education Abstracts, Educational research abstracts (ERA), EMBASE, ERIC (Education Resources Information Center), Linguistics & Language Behavior Abstracts, MEDLINE, Psycinfo, Public Affairs Index
  • Sayfa Sayıları: ss.623-629
  • Anahtar Kelimeler: Zonulin, Autism spectrum disorder, Gastrointestinal symptom, SPECTRUM DISORDERS, TIGHT JUNCTIONS, CELIAC-DISEASE, INTESTINAL PERMEABILITY, LARAZOTIDE ACETATE, GLUTEN, PATHOGENESIS, MODULATOR, BARRIER, BLIND
  • Gazi Üniversitesi Adresli: Evet

Özet

To evaluate the relationship between the severity of autism, severity of gastrointestinal symptoms and serum zonulin levels as a marker of increased intestinal permeability in children. Serum zonulin levels were determined in 56 children with ASDs and 55 healthy children. The severity of gastrointestinal symptoms and ASD symptoms was assessed with the Gastrointestinal Symptom Rating Scale (GSRS) and Childhood Autism Rating Scale (CARS), respectively. Serum zonulin levels were significantly higher than healthy controls in children with severe autism. A positive correlation was found between the CARS score, GSRS score and serum zonulin levels (r = ; P < .001). Our findings suggest that the severity of gastrointestinal symptoms and severity of autism might be related to increased intestinal permeability in ASDs children.