Flavonoid Derivatives from the Aerial Parts of Trifolium trichocephalum M. Bieb. and Their Antioxidant and Cytotoxic Activity

RENDA G., ÖZGEN U., Unal Z., SABUNCUOĞLU S., PALASKA E., ERDOĞAN ORHAN İ.

RECORDS OF NATURAL PRODUCTS, cilt.11, sa.5, ss.479-484, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.25135/acg.rnp.61.17.03.057
  • Dergi Adı: RECORDS OF NATURAL PRODUCTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.479-484
  • Anahtar Kelimeler: Antioxidant activity, cytotoxicity, Fabaceae, isoflavonoids, Trifolium trichocephalum, GLYCOSIDES
  • Gazi Üniversitesi Adresli: Evet

Özet

Trifolium L. species with a rich isoflavone content have been used as expectorant, analgesic, antiseptic, tonic, and wound- healer in folk medicine. The aim of the study is to evaluate pharmacological properties of the extracts and isolated compounds of T. tricocephalum. Phytochemical investigation of the aerial parts of T. trichocephalum led to the isolation of daidzein, genistein, quercetin, and daidzein 4'-O-beta-glucoside for the first time from this species. Isolated compounds along with the methanol extract, water, ethyl acetate and chloroform subextracts were tested for their radical scavenging and cytotoxic activity which was evaluated by MTT assay. According to the results of activity tests, extracts showed a concentration-dependent radical scavenging activity as well as cytotoxic effect on HepG2 cells at 400 mu g/mL, whereas the compounds did not exert any obvious cytotoxic effect at tested concentrations.