ABCB1 C3435T polymorphism is associated with susceptibility to major depression, but not with a clinical response to citalopram in a Turkish population

ÖZBEY, GÜL; Yucel, Berna; Taycan, Serap; Kan, Derya; Bodur, Nurdan; Arslan, Tayyibe; PERÇİN, FERDA; YÜKSEL, NEVZAT; Guzey, Cuneyt; ULUOĞLU, CANAN

doi:10.1016/j.pharep.2013.09.004

ABCB1 C3435T polymorphism is associated with susceptibility to major depression, but not with a clinical response to citalopram in a Turkish population

ÖZBEY G., Yucel B., Taycan S. E., Kan D., Bodur N. E., Arslan T., ...More

PHARMACOLOGICAL REPORTS, vol.66, no.2, pp.235-238, 2014 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 66 Issue: 2
Publication Date: 2014
Doi Number: 10.1016/j.pharep.2013.09.004
Journal Name: PHARMACOLOGICAL REPORTS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.235-238
Keywords: ABCB1, Polymorphism, Depression, Citalopram, Response, P-GLYCOPROTEIN GENE, MDR1 GENE, MULTIDRUG-RESISTANCE, IN-VITRO, BRAIN, PENETRATION, FREQUENCY, MICE, DISORDER, C1236T
Gazi University Affiliated: Yes

Abstract

Background: The ATP-binding cassette sub-family B member 1 (ABCB1) gene, which encodes the p-glycoprotein at the blood-brain barrier, is investigated for patients' susceptibility to major depressive disorder (MDD) and their therapeutic response to antidepressants. However, there is an inconsistency between the studies of different ethnic groups. The current study aimed to determine the potential correlations of the ABCB1 gene C3435T polymorphism with the susceptibility to MDD and the therapeutic response to citalopram in a Turkish population.