Bendiocarb induced histopathological and biochemical alterations in rat liver and preventive role of vitamins C and E

APAYDIN F. G., Bas H., KALENDER S., KALENDER Y.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, vol.49, pp.148-155, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49
  • Publication Date: 2017
  • Doi Number: 10.1016/j.etap.2016.11.018
  • Journal Name: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.148-155
  • Keywords: Bendiocarb, Vitamin C, Vitamin E, Liver toxicity, Oxidative stress, Histopathology, IN-VIVO, OXIDATIVE STRESS, PROTECTIVE ROLE, LIPID-PEROXIDATION, ANTIOXIDANT POWER, LEAD NITRATE, CHLORPYRIFOS, TISSUES, BLOOD, HEPATOTOXICITY
  • Gazi University Affiliated: Yes

Abstract

In this study, biochemical changes and histological structure of rat liver after bendiocarb administration and possible preventive effects of vitamins C and E were studied. The animals were given with bendiocarb, vitamin C and vitamin E, daily 0,8 mg/kg of body weight (bw), 100 mg/kg-bw and 100 mg/kg-bw for 28 days, respectively. Lipid peroxidation, antioxidant enzyme activities, histological alterations and antioxidant capacity assays of liver and also liver function tests and lipid profile were measured. Bendiocarb treatment decreased the antioxidant enzyme activities, FRAP and TEAC values and increased malondialdehyde levels compared to control. Also, there were statistically significant alterations in liver function tests, lipid profile parameters and histopathological changes in bendiocarb treated groups. Vitamins C and E showed protective effects against examining parameters. According to results we can say that co-treatment of vitamin C and vitamin E may be more effective than use of them alone. (C) 2016 Elsevier B.V. All rights reserved.