Evaluation of the chemopreventive effects of Hypericum perforatum L on DMBA-applied rat oral mucosa

Sengun D. N., KARACA İ. R., SARAÇ N., UĞUR A., FIRAT A., KAYMAZ F. F., ...More

ARCHIVES OF ORAL BIOLOGY, vol.127, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 127
  • Publication Date: 2021
  • Doi Number: 10.1016/j.archoralbio.2021.105139
  • Journal Name: ARCHIVES OF ORAL BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: 7,12-Dimethylbenzanthracene, Oral cancer, Carcinoma in situ, Hypericum perforatum L, Chemoprevention, ST-JOHNS-WORT, FERULIC ACID, CARCINOGENESIS, CANCER, ACTIVATION, EXPRESSION, HYPERFORIN, INDUCTION, DYSPLASIA, APOPTOSIS
  • Gazi University Affiliated: Yes

Abstract

Objective: Hypericum perforatum L also known as St. John's wort is known to have many beneficial properties for the organism including its antioxidant and anticancer activities. It is also known to have shown antiproliferative and cytotoxic effects against various cancer cell lines. The purpose of this study was to investigate the effects of Hypericum perforatum L on 7,12-dimethylbenz(a)anthracene-induced rat oral squamous cell carcinoma model.