Evaluation of the chemopreventive effects of Hypericum perforatum L on DMBA-applied rat oral mucosa

Sengun D. N., KARACA İ. R., SARAÇ N., UĞUR A., FIRAT A., KAYMAZ F. F., ...Daha Fazla

ARCHIVES OF ORAL BIOLOGY, cilt.127, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 127
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.archoralbio.2021.105139
  • Dergi Adı: ARCHIVES OF ORAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: 7,12-Dimethylbenzanthracene, Oral cancer, Carcinoma in situ, Hypericum perforatum L, Chemoprevention, ST-JOHNS-WORT, FERULIC ACID, CARCINOGENESIS, CANCER, ACTIVATION, EXPRESSION, HYPERFORIN, INDUCTION, DYSPLASIA, APOPTOSIS
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Hypericum perforatum L also known as St. John's wort is known to have many beneficial properties for the organism including its antioxidant and anticancer activities. It is also known to have shown antiproliferative and cytotoxic effects against various cancer cell lines. The purpose of this study was to investigate the effects of Hypericum perforatum L on 7,12-dimethylbenz(a)anthracene-induced rat oral squamous cell carcinoma model.