Starch-Based Membranes for Controlled Release of 5-Fluorouracil In Vitro


BERKKAN A. , KONDOLOT SOLAK E. , ASMAN G.

CHEMISTRYSELECT, vol.6, no.23, pp.5678-5684, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 23
  • Publication Date: 2021
  • Doi Number: 10.1002/slct.202100917
  • Title of Journal : CHEMISTRYSELECT
  • Page Numbers: pp.5678-5684
  • Keywords: 5-fluorouracil, Drug delivery, Green chemistry, Polymer, Starch, PVA membrane, ACID-WATER MIXTURES, GLASS-TRANSITION, TARGETED DELIVERY, CROSS-LINKING, RICE STARCH, PERVAPORATION SEPARATION, MICROSPHERES, TEMPERATURE, DYNAMICS, CANCER

Abstract

Starch is a natural polymer that is among the sustainable materials and has the characteristics of being a green material in harmony with nature. In this study, a potential transdermal release system was evaluated by investigating 5-fluorouracil (5-FU) transfer through starch/poly(vinyl alcohol) (PVA) membranes in vitro. The effects of membrane thickness, starch/PVA blending ratio, pH, and temperature on the release of 5-FU from the membranes were studied. At the end of the study, it was deduced that decrease in pH reduces the released amount of 5-FU from starch/PVA membranes and 5-FU transfer from membranes could be controlled within a fairly constant range. The diffusion coefficient was determined as 4.84x 10(-3), 4.49x 10(-3) and 2.54x 10(-3) cm(2) s(-1) for the pH of 7.4, 5.5, and 3.5, respectively. The activation energy for the permeation 5-FU from starch/PVA membrane (60/40, v/v) was found to be 9.72 kJ mol(-1).