Starch-Based Membranes for Controlled Release of 5-Fluorouracil In Vitro

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Berkkan A., Kondolot Solak E., Asman G.

CHEMISTRYSELECT, cilt.6, sa.23, ss.5678-5684, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 23
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/slct.202100917
  • Dergi Adı: CHEMISTRYSELECT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.5678-5684
  • Anahtar Kelimeler: 5-fluorouracil, Drug delivery, Green chemistry, Polymer, Starch, PVA membrane, ACID-WATER MIXTURES, GLASS-TRANSITION, TARGETED DELIVERY, CROSS-LINKING, RICE STARCH, PERVAPORATION SEPARATION, MICROSPHERES, TEMPERATURE, DYNAMICS, CANCER
  • Gazi Üniversitesi Adresli: Evet

Özet

Starch is a natural polymer that is among the sustainable materials and has the characteristics of being a green material in harmony with nature. In this study, a potential transdermal release system was evaluated by investigating 5-fluorouracil (5-FU) transfer through starch/poly(vinyl alcohol) (PVA) membranes in vitro. The effects of membrane thickness, starch/PVA blending ratio, pH, and temperature on the release of 5-FU from the membranes were studied. At the end of the study, it was deduced that decrease in pH reduces the released amount of 5-FU from starch/PVA membranes and 5-FU transfer from membranes could be controlled within a fairly constant range. The diffusion coefficient was determined as 4.84x 10(-3), 4.49x 10(-3) and 2.54x 10(-3) cm(2) s(-1) for the pH of 7.4, 5.5, and 3.5, respectively. The activation energy for the permeation 5-FU from starch/PVA membrane (60/40, v/v) was found to be 9.72 kJ mol(-1).