Synthesis and antimicrobial activities of unsymmetrical thioditetrazoles and their precursor thiotetrazoles

ÇAĞLAR TEKNİKEL Ö., ÖĞÜTCÜ H., DOYDUK D., DİŞLİ A.

ORGANIC COMMUNICATIONS, vol.16, no.4, pp.204-211, 2023 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 4
  • Publication Date: 2023
  • Doi Number: 10.25135/acg.oc.158.2309.2893
  • Journal Name: ORGANIC COMMUNICATIONS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier
  • Page Numbers: pp.204-211
  • Gazi University Affiliated: Yes

Abstract

In this study, a synthetic route to access unsymmetrical ditetrazoles was developed. By using this method, the first examples of unsymmetrical thioditetrazole compounds were synthesized. In vitro, antibacterial efficacy studies were carried out for all the thioditetrazoles and their precursor thiotetrazoles against ten bacteria. The synthesized compounds showed a strong antibacterial effect against pathogenic Gram-negative bacteria, especially Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa (up to 21 mm).