ORGANIC COMMUNICATIONS, vol.16, no.4, pp.204-211, 2023 (ESCI)
In this study, a
synthetic route to access unsymmetrical ditetrazoles was developed. By
using this method, the first examples of unsymmetrical thioditetrazole
compounds were synthesized. In vitro, antibacterial efficacy studies
were carried out for all the thioditetrazoles and their precursor
thiotetrazoles against ten bacteria. The synthesized compounds showed a
strong antibacterial effect against pathogenic Gram-negative bacteria,
especially Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa (up to 21 mm).