The role of fibroblast growth factor-2 in healing the dura mater after inducing cerebrospinal fluid leakage in rats

Nurata H., Cemil B., Kurt G., Ucankus N. L., Dogulu F., ÖMEROĞLU S.

JOURNAL OF CLINICAL NEUROSCIENCE, vol.16, no.4, pp.542-544, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 4
  • Publication Date: 2009
  • Doi Number: 10.1016/j.jocn.2008.05.021
  • Journal Name: JOURNAL OF CLINICAL NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.542-544
  • Keywords: Cerebrospinal fluid leakage, Dura mater, Fibroblast growth factor-2, Rat, SCAR FORMATION, MODEL, LAMINECTOMY, SUBSTITUTE, SEALANT, REPAIR
  • Gazi University Affiliated: Yes

Abstract

We conducted a study to determine the effectiveness of topically applied recombinant mouse fibroblast growth factor-2 (FGF-2) in healing the dura mater in a rat with dura mater injury and cerebrospinal fluid leakage. Laminectomies were performed in 32 rats at the level of the L2-L4 vertebrae, and a dura mater defect was created. Sixteen Fats were treated postoperatively with locally applied recombinant Mouse FGF-2, and 16 animals received normal saline. FGF-2 effects on dura mater healing, cerebrospinal fluid leakage, and wound healing were assessed at 3 and 6 weeks postoperatively. The extent of dura mater healing was evaluated by histological analysis. We found that dura mater healing was significantly increased (p < 0.05) in rats treated with FGF-2 compared with rats in the control group. In this experimental model, locally applied FGF-2 effectively increased dura mater healing and induced no side effects. (c) 2008 Elsevier Ltd. All rights reserved.