SYNERGISM BETWEEN UK 38485 AND ICI 185282 AGAINST DIGOXIN-INDUCED ARRHYTHMIAS IN GUINEA-PIGS

KANZIK I., ZENGIL H., IPEK N., CAKICI I., ABACIOGLU N., DORTLEMEZ H.

ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, cilt.312, ss.55-65, 1991 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 312
  • Basım Tarihi: 1991
  • Dergi Adı: ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.55-65
  • Gazi Üniversitesi Adresli: Hayır

Özet

In this study, the combination of a thromboxane synthetase inhibitor (UK 38 485) and a thromboxane receptor antagonist (ICI 185 282) was tested for an interaction of potential therapeutic importance and the effect of acetylsalicylic acid pretreatment on this combination was evaluated in digoxin-induced arrhythmias in guinea-pigs. Drug treatments at the dose combinations used (ICI 185 282: 0.2 mg/kg + 0.2 mg/kg/hr + UK 38 485 0.1 mg/kg/hr and ICI 185 282: 2 mg/kg + 2 mg/kg/hr + UK 38 485 1 mg/kg/hr) markedly reduced the incidence of ventricular fibrillation, mortality rate and arrhythmia score. Pretreatment with acetylsalicylic acid plus drug combination resulted in a dose-dependent increase in mortality rate and arrhythmia score.