Comparison of the Diagnostic Accuracy of Next Generation Sequencing and Microarray Resequencing Methods for Detection of BRCA1 and BRCA2 Gene Mutations

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Bahsi T., Ergun S. G., ERGÜN M. A., Percin E. F.

GAZI MEDICAL JOURNAL, vol.29, no.2, pp.116-118, 2018 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.12996/gmj.2018.32
  • Journal Name: GAZI MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.116-118
  • Keywords: BRCA1, BRCA2, breast cancer, microarray, next generation sequencing, HEREDITARY BREAST-CANCER
  • Gazi University Affiliated: Yes

Abstract

Objective: Breast cancer constitutes 29 % of estimated new cases of cancer in women, and it is also one of the major cause of death in all cancer types. In this study, DNA samples of familial breast cancer patients with BRCA1 and BRCA2 mutations which had been analyzed using conventional DNA sequencing method, were also analyzed with new methods including microarray and next generation sequencing (NGS) in order to compare their results