Successful Treatment of Paecilomyces variotii Peritonitis in a Liver Transplant Patient

Polat M., Kara S. S., TAPISIZ A., Demirtas Z., SARI S., KALKANCI A., ...More

MYCOPATHOLOGIA, vol.179, no.3-4, pp.317-320, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 179 Issue: 3-4
  • Publication Date: 2015
  • Doi Number: 10.1007/s11046-014-9854-1
  • Journal Name: MYCOPATHOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.317-320
  • Keywords: Amphotericin B, Liver transplant, Paecilomyces variotii peritonitis, Voriconazole, VORICONAZOLE, COMBINATION
  • Gazi University Affiliated: Yes

Abstract

Paecilomyces variotii has previously been reported as a causative pathogen for peritonitis in patients on continuous ambulatory peritoneal dialysis and shown to be usually sensitive to amphotericin B and resistant to voriconazole. We report the first case, to our knowledge, of P. variotii peritonitis in a liver transplant patient, which was unresponsive to initial liposomal amphotericin B (L-AmB) treatment and resolved dramatically after the addition of voriconazole. The present case provides evidence for the clinical and microbiological effectiveness of voriconazole combined with L-AmB in treating P. variotii peritonitis refractory to initial L-AmB treatment.