Akademik Veri Yönetim Sistemi
TÜRKİYE KLİNİKLERİ, Ankara, 2023
ABSTRACT
Aging is identified as a progressive loss of functional capacities of most organs, plus a reduction in response to receptor stimulation and homeostatic mechanisms. The importance of age-related changes in drug sensitivity is increasingly understood. The administration of pharmacological agents to older persons often results in a higher incidence of adverse drug reactions compared with the young. This is mainly due to changes in pharmacokinetic and pharmacodynamic properties linked to the aging. While pharmacokinetic changes in the elderly are usually well known and predicted easily, pharmacodynamic changes are understood hardly. Sensitivity to many agents affecting particularly cardiovascular and central nervous system becomes apparent in elderly. Understanding the mechanisms of aging and the biological consequence which they bring about could help answer questions concerning the pharmacodynamic changes observed in the elderly. In addition, this understanding forms the basis of providing of rational drug use in the elderly.