In vitro activity of eravacycline in combination with colistin against carbapenem-resistant A. baumannii isolates

ÖZGER H. S., Cuhadar T., Yildiz S. S., Gulmez Z. D., DİZBAY M., GÜZEL TUNÇCAN Ö., ...More

JOURNAL OF ANTIBIOTICS, vol.72, no.8, pp.600-604, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 8
  • Publication Date: 2019
  • Doi Number: 10.1038/s41429-019-0188-6
  • Journal Name: JOURNAL OF ANTIBIOTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.600-604
  • Gazi University Affiliated: Yes

Abstract

The synergistic activity of eravacycline in combination with colistin on carbapenem-resistant A. baumannii (CRAB) isolates was evaluated in this study Minimum inhibitory concentrations (MICs) of eravacycline and colistin were determined by the broth microdilution method. MICs values ranged between 1 to 4 mg and 0.5 to 256 mgl(-1) for eravacycline and colistin, respectively. In vitro synergy between eravacycline and colistin was evaluated by using the chequerboard methodology. Synergistic activity was found in 10% of the strains, and additive effect in 30%. No antagonism was detected. Similar activity was also observed in colistin-resistant CRAB isolates. The result of this study indicates that eravacycline and colistin combination may be a potential therapeutic option for the treatment of CRAB related infections.