Effects of phase I periodontal treatment on gingival crevicular fluid levels of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1

Tuter G., Kurtis B., SERDAR M. A.

JOURNAL OF PERIODONTOLOGY, vol.73, no.5, pp.487-493, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 5
  • Publication Date: 2002
  • Doi Number: 10.1902/jop.2002.73.5.487
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.487-493
  • Keywords: periodontitis/therapy, gingival crevicular fluid/analysis, matrix metalloproteinases, matrix metalloproteinase tissue inhibitors, LOCALIZED JUVENILE PERIODONTITIS, MESSENGER-RNA, COLLAGENASE ACTIVITY, ADULT PERIODONTITIS, HUMAN NEUTROPHIL, EXPRESSION, TIMP-1, GELATINASE, DISEASE, IDENTIFICATION
  • Gazi University Affiliated: Yes

Abstract

Background: Matrix metalloproteinase-1 (MMP-1) is a member of a family of enzymes which are capable of degrading most extracellular matrix macromolecules. Extracellular control of MMPs is exerted by tissue inhibitors of metalloproteinases (TIMP) and by mechanisms of pro-MMP activation. Levels of MMPs and TIMPs change during healing, inflammation, and normal tissue turnover. The aim of this study was to evaluate the effects of phase I periodontal treatment on gingival crevicular fluid (GCF) levels of MMP-1 and TIMP-1.