Oral Focal Epithelial Hyperplasia: Report of 3 Cases With Human Papillomavirus DNA Sequencing Analysis

Gultekin S. E. , YILDIRIM B. , Sarisoy S.

PEDIATRIC DENTISTRY, vol.33, no.7, pp.522-524, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 7
  • Publication Date: 2011
  • Title of Journal : PEDIATRIC DENTISTRY
  • Page Numbers: pp.522-524


Focal epithelial hyperplasia (FEH), or Heck's disease, is a benign proliferative viral infection of the oral mucosa that is related to Human Papillomavirus (HPV), mainly subtypes 13 and 32. Although this condition is known to exist in numerous populations and ethnic groups, the reported cases among Caucasians are relatively rare. It presents as asymptomatic papules or nodules on the oral mucosa, gingiva, tongue, and lips. Histopothologically, it is characterized by parakeratosis, epithelial hyperplasia, focal acanthosis, fusion, and horizontal outgrowth of epithelial ridges and the cells named mitozoids. The purpose of this case report was to present 3 cases of focal epithelial hyperplasia in a pediatric age group. Histopathological and clinical features of cases are discussed and DNA sequencing analysis is reported in which HPV 13, HPV 32, and HPV 11 genomes are detected. (Pediatr Dent 2011;33:522-4) Received March 23, 2010 vertical bar Last Revision September 28, 2010 vertical bar Accepted October 4, 2010