Evaluation of the Effects of Recurrent Dexmedetomidine on Cognitive Functions and Brain Tissue in Streptozotocin-Induced Rats with Alzheimer's Disease

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ARSLAN M., KÜÇÜK A., Kiran M. M., KÖKSAL Z., KURTİPEK Ö., KAVUTÇU M.

GAZI MEDICAL JOURNAL, vol.33, no.1, pp.5-9, 2022 (ESCI)

• Publication Type: Article / Article
• Volume: 33 Issue: 1
• Publication Date: 2022
• Doi Number: 10.12996/gmj.2022.02
• Journal Name: GAZI MEDICAL JOURNAL
• Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier
• Page Numbers: pp.5-9
• Keywords: Alzheimer, dexmedetomidine, Radial Arm Maze Test, rat, GFAP, TBARS, Catalase, GENERAL-ANESTHESIA, DYSFUNCTION, EXPOSURE, SURGERY, PHOSPHORYLATION, OLIGOMERIZATION, ISOFLURANE, RISK
• Gazi University Affiliated: Yes

Abstract

Objective: The aim of this study was to evaluate the effects of recurrent dexmedetomidine on cognitive functions and brain histopathology in the elderly rat model which has Alzheimer disease created with streptozocin (STZ).