Oxidized low-density lipoprotein levels and carotid intima-media thickness as markers of early atherosclerosis in prepubertal obese children
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.26, pp.657-662, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 26
- Publication Date: 2013
- Doi Number: 10.1515/jpem-2012-0374
- Journal Name: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.657-662
- Keywords: carotid IMT, oxidized LDL, prepubertal obesity, CARDIOVASCULAR RISK-FACTORS, AMBULATORY BLOOD-PRESSURE, ENDOTHELIAL DYSFUNCTION, INSULIN-RESISTANCE, CHILDHOOD OBESITY, FAMILIAL HYPERCHOLESTEROLEMIA, HEALTHY POPULATION, METABOLIC SYNDROME, ADOLESCENT GIRLS, TURKISH CHILDREN
- Gazi University Affiliated: Yes
Abstract
Objectives: Children with obesity have a high cardiovascular risk and an impaired oxidant-antioxidant status, which may lead to endothelial dysfunction and increased carotid intima media thickness (IMT) even in childhood. The aim of this study was to investigate the circulating oxidized low-density lipoprotein (LDL) concentrations and the IMT of carotid arteries in prepubertal obese children, and also to search for its possible association with carotid atherosclerosis.