Retrospective analysis of the association of the expression and single nucleotide polymorphisms (SNPs) of the TLR4, PTX3 and Dectin-1 (CLEC/A) genes with development of invasive aspergillosis among haematopoietic stem cell transplant recipients with oncohaematological disorders

Kalkancı A., Tuğ E., Fidan I., Güzel Tunçcan Ö., Özkurt Z. N., Yegin Z. A., ...More

MYCOSES, vol.63, pp.832-839, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63
  • Publication Date: 2020
  • Doi Number: 10.1111/myc.13087
  • Journal Name: MYCOSES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.832-839
  • Keywords: Dectin-1 (CLEC/A), invasive aspergillosis, PTX3, RNA expression analyses, single nucleotide polymorphisms, stem cell transplant recipients, TLR4, PULMONARY ASPERGILLOSIS, FUNGAL-INFECTIONS, HUMAN DECTIN-1, SUSCEPTIBILITY, PROMOTER, RECOGNITION, DEFICIENCY, RECEPTORS, DISEASE, RISK
  • Gazi University Affiliated: Yes

Abstract

Objectives Several studies described single nucleotide polymorphisms (SNPs) on pattern recognition receptor (PRR) such as toll-like receptors (TLRs), dendritic cell-associated C-type lectin-1 (Dectin-1/CLEC7A) genes of patients with invasive fungal infections (IFIs) caused by Candida and Aspergillus. We screened TLR4, Dectin-1 and PTX3 polymorphisms in a Turkish population with invasive aspergillosis (IA) underlying haematological malignancies.