The synthesis and investigation of the antimicrobial activity of some new phenylselanyl-1-(toluene-4sulfonyl)-1H-tetrazole derivatives

YILDIRIR Y., Us M. F., Colak N., ÖZKAN H., YAVUZ S., DİŞLİ A., ...More

MEDICINAL CHEMISTRY RESEARCH, vol.18, no.2, pp.91-97, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1007/s00044-008-9110-7
  • Journal Name: MEDICINAL CHEMISTRY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.91-97
  • Keywords: Tetrazole toluenesulfonic acid, Antimicrobial activity, SMX, SRZ, IDENTIFICATION, INHIBITORS, CHEMISTRY
  • Gazi University Affiliated: Yes

Abstract

The sulfonamide functional group has aroused interest in both medicinal and bioorganic chemistry. In this study, some new phenylselanyl-1-(toluene-4-sulfonyl)-1H-tetrazole derivatives (2a-f) have been synthesized using dicyclohexylcarbodiimide/dimethylaminopyridine (DCC/DMAP). The structures of the presently synthesized compounds were elucidated by spectroscopic methods [Fourier-transform infrared (FTIR) spectroscopy, (1)H nuclear magnetic resonance (NMR), (13)C nuclear magnetic resonance-attached proton test ((13)C NMR-APT), and mass spectrometry (MS)]. In addition, the antimicrobial activity of the synthesized compounds and two antibiotics [sulfamethoxazole (SMX) and sulfamerazine (SRZ)] were investigated against some microorganisms.