Evaluation of Oxidative Stress in Bipolar Disorder in terms of Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index


Cingi Yirun M., ÜNAL K. , Altunsoy Sen N., Yirun O., Aydemir C., Goka E.

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, vol.53, no.3, pp.194-198, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.5152/npa.2015.10123
  • Title of Journal : NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Page Numbers: pp.194-198
  • Keywords: Bipolar disorder, total antioxidant status, total oxidant status, oxidative stress, SUPEROXIDE-DISMUTASE, NITRIC-OXIDE, MANIC EPISODE, SCHIZOPHRENIA, MARKERS, POPULATION

Abstract

Introduction: Bipolar disorder is one of the most debilitating psychiatric disorders characterized by disruptive episodes of mania/hypomania and depression. Considering the complex role of biological and environmental factors in the etiology of affective disorders, recent studies have focused on oxidative stress, which may damage nerve cell components and take part in pathophysiology. The aim of the present study was to contribute to the data about oxidative stress in bipolar disorder by detecting the total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) levels of manic episode (ME) and euthymic (EU) patients and by comparing these results with those of healthy controls (HCs).