Chronic daily cortical spreading depressions suppress spreading depression susceptibility
CEPHALALGIA, cilt.31, sa.16, ss.1601-1608, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 16
- Basım Tarihi: 2011
- Doi Numarası: 10.1177/0333102411425865
- Dergi Adı: CEPHALALGIA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1601-1608
- Anahtar Kelimeler: Spreading depression, chronic migraine, astrocyte, MIGRAINE, SPECTRUM, MOUSE, CLASSIFICATION, ASTROCYTES, GLUTAMATE, HEADACHE, INJURY, ONSET, MICE
- Gazi Üniversitesi Adresli: Evet
Özet
Background: Migraine is a disabling chronic episodic disorder. Attack frequency progressively increases in some patients. Incremental cortical excitability has been implicated as a mechanism underlying progression. Cortical spreading depression (CSD) is the electrophysiological event underlying migraine aura, and a headache trigger. We hypothesized that CSD events during frequent migraine attacks condition the cortex to increase the susceptibility to further attacks.