Angiotensin-Converting Enzyme Inhibitor Reduces Radiation-Induced Periprosthetic Capsular Fibrosis

Erpolat, ÖZGE; Senturk, MUHAMMED; Saribas, Sanem; Pasinlioglu, Burak; Gulbahar, ÖZLEM; Tuncer, Serhan; Demircan, Volkan; Catli Dinc, SERAP; Polat, Omer; Elmas, ÇİĞDEM

doi:10.1016/j.jss.2021.01.033

Angiotensin-Converting Enzyme Inhibitor Reduces Radiation-Induced Periprosthetic Capsular Fibrosis

Erpolat Ö. P., Senturk E., Saribas S., Pasinlioglu B., Gulbahar Ö., Tuncer S., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.263, ss.167-175, 2021 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 263
Basım Tarihi: 2021
Doi Numarası: 10.1016/j.jss.2021.01.033
Dergi Adı: JOURNAL OF SURGICAL RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
Sayfa Sayıları: ss.167-175
Anahtar Kelimeler: Silicone capsule, Radiation, ACE inhibitor, Ramipril, Fibrosis, Contracture, BREAST-CANCER PATIENTS, MATRIX METALLOPROTEINASES, TISSUE INHIBITORS, MURINE MODEL, TGF-BETA-1, RECONSTRUCTION, RADIOTHERAPY, CONTRACTURE, CYTOKINES, IMPLANTS
Gazi Üniversitesi Adresli: Evet

Özet

Background: The capsular contracture is one of the main complications after radiotherapy in patients with implant-based reconstruction. The aim of this study is to evaluate the efficacy of ramipril for the prevention of radiation-induced fibrosis around the silicone implant.