Gelatinase B expression as a prognostic factor in patients with stage II/III rectal carcinoma treated by postoperative adjuvant therapy.

Unsal D., AKYÜREK N., ÜNER A., Erpolat P., Han U., AKMANSU M., ...More

American journal of clinical oncology, vol.31, no.1, pp.55-63, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1097/coc.0b013e318068b4e2
  • Journal Name: American journal of clinical oncology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.55-63
  • Keywords: rectal cancer, radiotherapy, matrix metalloproteinase, gelatinase, prognostic factor, COLORECTAL-CANCER, TISSUE INHIBITOR, MATRIX METALLOPROTEINASES, MMP-2, MATRILYSIN, TIMP-2
  • Gazi University Affiliated: Yes

Abstract

Objective: The matrix-metalloproteinases (MMPs) are thought to be critically involved in tumor invasion and metastasis. This retrospective study was aimed both to examine the gelatinase expression status in patients with rectal cancer and to investigate their prognostic value on survival.