Therapy-related refractory anemia with ringed sideroblasts in chronic lymphocytic leukemia: involvement of 3q21 region

Yagci M., Sucak G., Ogur G., Haznedar R.

CANCER GENETICS AND CYTOGENETICS, cilt.129, sa.1, ss.43-46, 2001 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 129 Sayı: 1
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0165-4608(01)00423-x
  • Dergi Adı: CANCER GENETICS AND CYTOGENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.43-46
  • Gazi Üniversitesi Adresli: Evet

Özet

Therapy-related myelodysplastic syndrome/acute myelogenous leukemia (t-MDS/AML) is extremely rare in chronic lymphocytic leukemia (CLL) despite extensive use of alkylating agents. We present a case of heavily treated CLL with resultant therapy-related refractory anemia with ringed sideroblasts (RARS). A complex cytogenetic abnormality including involvement of 3q21 was detected and to our knowledge, is the first report of a RARS case with a 3q21 abnormality. (C) 2001 Elsevier Science Inc. All rights reserved.