Hepatotoxicity associated with lapatinib in an experimental rat model


Demirci U., Buyukberber S., Yilmaz G., KEREM M., Coskun U., ÜNER A., ...More

EUROPEAN JOURNAL OF CANCER, vol.48, no.2, pp.279-285, 2012 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.1016/j.ejca.2011.10.011
  • Journal Name: EUROPEAN JOURNAL OF CANCER
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.279-285
  • Keywords: Lapatinib, Rat, Hepatotoxicity, COLORECTAL LIVER METASTASES, BREAST-CANCER, PREOPERATIVE CHEMOTHERAPY, ADJUVANT CHEMOTHERAPY, DUAL INHIBITOR, RECEPTOR, GROWTH, TRASTUZUMAB, OXALIPLATIN, FAMILY

Abstract

Background: The current study is the first to evaluate the biochemical and histopathological features of hepatic toxicity of lapatinib.