Determination of Paracetamol Based on 3-amino-4H-1,2,4-triazole Coated Glassy Carbon Surface in Pharmaceutical Sample

Uzun D.

ELECTROANALYSIS, vol.33, no.7, pp.1699-1706, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.1002/elan.202100002
  • Journal Name: ELECTROANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.1699-1706
  • Keywords: Modified electrode, 3-amino-4H-1, 2, 4-triazole, paracetamol, pharmaceutical
  • Gazi University Affiliated: Yes

Abstract

In this present study, to determine paracetamol, an electroanalytical method is presented using differential pulse voltammetry (DPV) at 3-amino-4H-1,2,4-triazole (3AT) coated glassy carbon (GC) electrode. The electrochemical characterization and electron transfer behavior of this prepared electrode in the mixture of K-4[Fe(CN)(6)]/K-3[Fe(CN)(6)] contains 0.1 M KCl was confirmed by using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) methods. Furthermore, scanning electron microscopy (SEM) was used to observe morphological structures of the bare and modified surfaces. The effect of pH was studied on the redox reaction of paracetamol in phosphate buffer in the range of pH 3.0-9.0. The limit of detection was 0.043 mu M (3 s/m) for 3AT-GC electrode. The developed electrode was successfully utilized in pharmaceutical samples.