Effect of Intraoperative Platelet-Rich Plasma and Fibrin Glue Application on Skin Flap Survival

Findikcioglu F., FINDIKÇIOĞLU K., Yavuzer R., Lortlar N., Atabay K.

JOURNAL OF CRANIOFACIAL SURGERY, cilt.23, sa.5, ss.1513-1517, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1097/scs.0b013e3182597ce6
  • Dergi Adı: JOURNAL OF CRANIOFACIAL SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1513-1517
  • Anahtar Kelimeler: Platelet-rich plasma, fibrin glue, thrombin, flap survival, ENDOTHELIAL GROWTH-FACTOR, THERAPEUTIC ANGIOGENESIS, RAT, ANASTOMOSES, IMPROVEMENT, EXPRESSION, SEALANT, VEGF, GEL
  • Gazi Üniversitesi Adresli: Evet

Özet

The experiment was designed to compare the effect of intraoperative platelet-rich plasma (PRP) and fibrin glue application on skin flap survival. In this study, bilateral epigastric flaps were elevated in 24 rats. The right-side flaps were used as the control of the left-side flaps. Platelet-rich plasma, fibrin glue, and thrombin had been applied under the flap sites in groups 1, 2, and 3, respectively. Five days later, all flap pedicles were ligated. Necrotic area measurements, microangiography, and histologic and immunohistochemical evaluations were performed to compare the groups.