Synthesis, characterization, and antimicrobial activity of copper(II) complexes with N,N '-propanediyl-bis-benzenesulfonamide and N,N '-ethanediyl-bis-2-methylbenzenesulfonamide

Alyar S., ÖZBEK N., OCAK İSKELELİ N., KARACAN N.

MEDICINAL CHEMISTRY RESEARCH, cilt.22, sa.5, ss.2051-2060, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s00044-012-0171-2
  • Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2051-2060
  • Anahtar Kelimeler: Sulfonamide Cu(II) complexes, Antimicrobial activity, Disk diffusion method, MICs, CRYSTAL-STRUCTURE, ELECTROCHEMICAL SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION, ANTIBACTERIAL ACTIVITY, MAGNETIC-PROPERTIES, SULFONAMIDES, DERIVATIVES, NICKEL(II), BASES, EPR
  • Gazi Üniversitesi Adresli: Evet

Özet

Copper(II) complexes of new aryldisulfonamides (L (1) = N,N'-bis[(2-methylphenyl)sulfonyl]ethylenediamine) and L (2) = N,N'-propanediyl-bis-benzenesulfonamide with 1,10-phenanthroline have been synthesized and characterized by using elemental analyses, FT-IR, LCMS, conductivity, and magnetic susceptibility techniques. The structures of [Cu(phen)(2)]L-1 (1) and [CuL2(phen)(2)] (2) compounds have been determined. Complex (1) has also been characterized by single crystal X-ray diffraction. The complex (1) crystallizes in the triclinic system, space group P1, with cell constants a = 12.9353(8) , b = 13.8543(9) , c = 14.4513(10) , alpha = 103.593(5)A degrees, beta A = 113.713(5)A degrees, gamma A = 106.104(5)A degrees, and Z = 1. The antibacterial activities of synthesized compounds were studied against Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, and B. cereus and Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, and Yersinia enterocolitica by microdilution (as MICs in mu g/mL) and disk diffusion (as diameter zone in mm) method. The biological activity screening showed that (1) has more activity than (2) against the tested bacteria.