Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and A beta-Aggregation Inhibitors

Kılıç B. , Erdogan M., Gulcan H. O. , Aksakarl F., Oruklu N. , Bağrıaçık E. Ü. , ...More

MEDICINAL CHEMISTRY, vol.15, no.1, pp.59-76, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.2174/1573406414666180524073241
  • Title of Journal : MEDICINAL CHEMISTRY
  • Page Numbers: pp.59-76
  • Keywords: Alzheimer's disease, pyridazinone, acetylcholinesterase inhibitory activity, butyrylcholinesterase inhibitory activity, molecular docking, rational drug design, 1(2H)-PHTHALAZINONE DERIVATIVES, E2020 ARICEPT(R), ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, TOXICITY, BINDING, AGENTS, SITE


Background: With respect to the increase in the average life expectancy, Alzheimer Disease (AD), the most common form of age-related dementia, has become a major threat to the population over the age of 65 during the past several decades. The majority of AD treatments are focused on cholinergic and amyloid hypotheses.