MEDICINAL CHEMISTRY, vol.15, no.1, pp.59-76, 2019 (Journal Indexed in SCI)
Article / Article
Title of Journal :
Alzheimer's disease, pyridazinone, acetylcholinesterase inhibitory activity, butyrylcholinesterase inhibitory activity, molecular docking, rational drug design, 1(2H)-PHTHALAZINONE DERIVATIVES, E2020 ARICEPT(R), ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, TOXICITY, BINDING, AGENTS, SITE
Background: With respect to the increase in the average life expectancy, Alzheimer Disease (AD), the most common form of age-related dementia, has become a major threat to the population over the age of 65 during the past several decades. The majority of AD treatments are focused on cholinergic and amyloid hypotheses.