Synthesis, analgesic, and anti-inflammatory activities of [6-(3,5-dimethyl-4-chloropyrazole-1-yl)-3(2H-pyridazinon-2-yl]acetamides


Sukuroglu M. K. , Ergun B., Unlu S., Sahin M., Kupeli E., Yesilada E., ...More

ARCHIVES OF PHARMACAL RESEARCH, vol.28, no.5, pp.509-517, 2005 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 5
  • Publication Date: 2005
  • Doi Number: 10.1007/bf02977751
  • Journal Name: ARCHIVES OF PHARMACAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.509-517
  • Keywords: pyridazinone, pyrazole, analgesic, anti-inflammatory, writhing, carrageenan, AMIDE DERIVATIVES, PYRIDAZINONE DERIVATIVES, ANTINOCICEPTIVE ACTIVITY, DIFFERENTIAL INHIBITION, CLINICAL-SIGNIFICANCE, DRUGS

Abstract

A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4-chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analgesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.