Are serum nitric oxide and vascular endothelial growth factor levels affected by packed red blood cell transfusions?

Ergenekon E., Bozkaya D., Goktas T., Erbas D., ATAK YÜCEL A., Turan O., ...More

HEMATOLOGY, vol.15, no.3, pp.170-173, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1179/102453309x12583347113456
  • Journal Name: HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.170-173
  • Keywords: NO, VEGF, PRBC transfusion, HYPOXIC VASODILATION, HEMOGLOBIN, EXPRESSION, NO
  • Gazi University Affiliated: Yes

Abstract

Background: Nitric oxide (NO) and vascular endothelial growth factor (VEGF) are important mediators for hemodynamics and angiogenesis in the body. NO coming from endothelial cells and red blood cells is particularly effective in hypoxic vasodilation. VEGF has known effects on the induction of NO synthesis and is also known to be affected by blood product transfusions. The objectives of this study were to measure NO and VEGF levels before and after packed red blood cell (PRBC) transfusions.