Intraventricular treatment of paediatric meningitis due to extensively drug-resistant Gram-negative bacteria: two case reports and review of the literature

DENİZ M., TAPISIZ A., BÖRCEK A. Ö., TEZER H.

JOURNAL OF CHEMOTHERAPY, vol.33, no.7, pp.509-516, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 33 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.1080/1120009x.2021.1920249
  • Journal Name: JOURNAL OF CHEMOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.509-516
  • Keywords: Intraventricular treatment, Nosocomial meningitis, Children, Neurosurgery, Gram-negative bacterial infections, Drug resistance, Bacterial, Colistin, MULTIRESISTANT ACINETOBACTER-BAUMANNII, CRITICALLY-ILL PATIENTS, MULTIDRUG-RESISTANT, INTRATHECAL COLISTIN, CEREBROSPINAL-FLUID, POLYMYXIN-B, VENTRICULITIS, INFECTIONS
  • Gazi University Affiliated: Yes

Abstract

Nosocomial meningitis caused by Gram-negative bacteria is associated with increasingly common neurosurgical procedures in children, with an increase in incidence recently reported. These infections are associated with an increased risk of mortality, prolonged hospitalisation, and increased costs. In this report, we describe two paediatric cases with central nervous system infections caused by extensively drug-resistant Gram-negative bacteria that were successfully treated with intraventricular colistin. To the best of our knowledge, this is the first comprehensive review and discussion of intraventricular antimicrobial therapy in a paediatric population. Based on our comprehensive review of the relevant literature, it appears that intraventricular administration of colistin may be a promising and effective option in the treatment of central nervous system infections in children who do not respond to other treatment options.