Akademik Veri Yönetim Sistemi
Materials Today Communications, cilt.49, 2025 (SCI-Expanded)
In this study, the copper (II) complex of a hydrazone Schiff base ligand with acrylate functionality was synthesized by condensing 3-ethoxy salicylaldehyde with isobutyrohydrazide. The acrylate-functionalized Cu(II) hydrazone complex was covalently incorporated into the polyurethane-based coating in varying ratios under UV light. Its effects on antibacterial activity for surface coatings were then investigated. The antimicrobial activity of coatings containing Cu(II) hydrazone complexes was evaluated using disk diffusion assays and SEM micrographs. Compared to the 14 mm inhibition zone produced by the reference antibiotic gentamicin, coatings containing different concentrations of Cu(II) complexes (2.5 %, 5 %, and 10 %) exhibited inhibition zones of 8 mm, 10 mm, and 11 mm, respectively, against Pseudomonas aeruginosa ATCC 27853. For Candida albicans ATCC 10231, the coating containing 2.5 % metal complex showed no inhibitory activity. However, the 5 % and 10 % coatings produced inhibition zones of 10 mm and 12 mm, respectively, with the latter matching the effectiveness of fluconazole. Additionally, the growth inhibition of Pseudomonas aeruginosa and Candida albicans in UV-cured antimicrobial coatings was assessed through SEM analysis. SEM micrographs revealed a significant reduction in microbial cell density both Pseudomonas aeruginosa and Candida albicans at higher Cu(II) complex concentrations.