The Role of Secondary Metabolites on Gynecologic Cancer Therapy: Some Pathways and Mechanisms

Creative Commons License

DEMİREL M. A., SÜNTAR İ.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.14, sa.3, ss.324-334, 2017 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 14 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tjps.49368
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.324-334
  • Anahtar Kelimeler: Gynecologic cancers, pathway, secondary metabolites, phytoconstituents, inflammation, NF-KAPPA-B, APIGENIN INDUCES APOPTOSIS, INFLAMMATORY BREAST-CANCER, X-LINKED INHIBITOR, OVARIAN-CANCER, CELL-GROWTH, IN-VITRO, FLAVONOID PHYTOCHEMICALS, SIGNALING PATHWAY, DNA-SYNTHESIS
  • Gazi Üniversitesi Adresli: Evet

Özet

Gynecologic cancers are among the most common cancers in humans and animals. Treatment success depends on several factors including stage at diagnosis, tumor type, origin and metastasis. Currently, surgery, chemotherapy, and radiotherapy are preferred in the treatment of these cancers. However, many anticarcinogenic drugs can cause severe adverse effects and also the expected response to treatment may not be obtained. In recent studies, the importance of the relationship between cancer and inflammation has been emphasized. Therefore, several phytochemicals that exhibit beneficial bioactive effects towards inflammatory pathways were proven to have anticarcinogenic potential for gynecologic cancer therapy. This review summarizes the role of inflammatory pathways in gynecologic cancers and effective secondary metabolites for cancer therapy.