Preventive effect of Rumex crispus L. on surgically induced intra-abdominal adhesion model in rats

SÜNTAR İ., DEMİREL M. A., ÇERİBAŞI A. O., ERGİN İ., GÖKBULUT A.

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, vol.29, no.1, pp.101-115, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.1007/s40199-021-00387-8
  • Journal Name: DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, CINAHL, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.101-115
  • Gazi University Affiliated: Yes

Abstract

Background Rumex crispus L. (Polygonaceae), known as "Labada" in Turkey, was reported to be used for the treatment of gynecological diseases such as postpartum complications and infertility in folk medicine. Earlier studies on R. crispus have shown that leaf, fruit and root extracts have anti-inflammatory and antioxidant activities and are used for the treatment of tumors in the uterus. The hypothesis of this study is that R. crispus may generate potential anti-adhesive activity against complex factors such as inflammation, oxidation and fibrosis.