Iron homeostasis is altered in response to hypoxia and hypothermic preconditioning in brain glial cells

Aral L. A., Ergün M. A., Engin A. B., Börcek A. Ö., Belen H. B.

Turkish journal of medical sciences, vol.50, no.8, pp.2005-2016, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 8
  • Publication Date: 2020
  • Doi Number: 10.3906/sag-2003-41
  • Journal Name: Turkish journal of medical sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.2005-2016
  • Keywords: Hypoxic brain injury, glia, iron, ferritin, hypothermia, preconditioning, PERIVENTRICULAR WHITE-MATTER, AMEBOID MICROGLIAL CELLS, THERAPEUTIC HYPOTHERMIA, INFLAMMATORY RESPONSE, METABOLIC ADAPTATION, REGULATORY PROTEINS, LIGHT-CHAIN, INJURY, MECHANISMS, TOLERANCE
  • Gazi University Affiliated: Yes

Abstract

Background/aim: Altered iron metabolism is one of the pathophysiological mechanisms occurring during hypoxic injuries in the central nervous system. Proper homeostasis of cellular iron is regulated by iron import, storage, and export proteins that prevent excess iron overload or iron starvation in cells. Therapeutic hypothermia is an approved treatment for hypoxic ischemia in newborns, but the underlying molecular mechanism is still unknown. We studied the effects of hypoxia, preceded with preconditioning, on the iron homeostasis of glial cells, known as a major actor in the inflammatory process during perinatal brain injury.