Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat

Cakmak, G.; Irkorucu, O.; Ucan, B.; Emre, A.; Bahadir, B.; Demirtas, CANAN; Tascilar, O.; Karakaya, K.; Acikgoz, S.; Kertis, G.; Ankarali, H.; Pasaoglu, HATİCE; Comert, M.

doi:10.1007/s11605-009-0951-2

Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat

Cakmak G. K., Irkorucu O., Ucan B. H., Emre A. U., Bahadir B., Demirtas C., ...Daha Fazla

JOURNAL OF GASTROINTESTINAL SURGERY, cilt.13, sa.9, ss.1707-1716, 2009 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 13 Sayı: 9
Basım Tarihi: 2009
Doi Numarası: 10.1007/s11605-009-0951-2
Dergi Adı: JOURNAL OF GASTROINTESTINAL SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1707-1716
Anahtar Kelimeler: Simvastatin, Wound healing, Anatomosis, Dehiscence, Bursting pressure, Hydroxyproline, SMOOTH-MUSCLE-CELLS, COLORECTAL-CANCER, COLONIC ANASTOMOSES, CURATIVE RESECTION, STATINS, RISK, REPERFUSION, SECRETION, SURVIVAL, LEAKAGE
Gazi Üniversitesi Adresli: Evet

Özet

Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor commonly known as a cholesterol-lowering drug with additional pleiotropic effects. Also, it is demonstrated that it prevents postoperative peritoneal adhesions in rat. This study was designed to assess its effects on the healing process of colonic anastomosis.