Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat


Cakmak G. K., Irkorucu O., Ucan B. H., Emre A. U., Bahadir B., Demirtas C., ...Daha Fazla

JOURNAL OF GASTROINTESTINAL SURGERY, cilt.13, sa.9, ss.1707-1716, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 9
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s11605-009-0951-2
  • Dergi Adı: JOURNAL OF GASTROINTESTINAL SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1707-1716
  • Anahtar Kelimeler: Simvastatin, Wound healing, Anatomosis, Dehiscence, Bursting pressure, Hydroxyproline, SMOOTH-MUSCLE-CELLS, COLORECTAL-CANCER, COLONIC ANASTOMOSES, CURATIVE RESECTION, STATINS, RISK, REPERFUSION, SECRETION, SURVIVAL, LEAKAGE
  • Gazi Üniversitesi Adresli: Evet

Özet

Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor commonly known as a cholesterol-lowering drug with additional pleiotropic effects. Also, it is demonstrated that it prevents postoperative peritoneal adhesions in rat. This study was designed to assess its effects on the healing process of colonic anastomosis.